A complete overview of the chiral field including research relevant to synthesis, analytic chemistry, catalysis and pharmaceuticals.
Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Contributors.
Contents.
Preface.
1: Introduction: The Importance of Chirality in Drugs and Agrochemicals.
2: Importance of Chirality in the Field of Anti-Infective Agents.
3: Chirality in Antibacterial Agents.
4: Diastereomers, Enantiomers and Bioactivity. TMC207: A New Candidate for the Treatment of Tuberculosis.
5: Fluorine in Medicinal Chemistry: Importance of Chirality.
6: Peptides and Chirality Effects on the Conformation and the Synthesis of Medicinally Relevant Peptides.
7: Stereochemical Lability in Drug Molecules: Cases where Chirality may not be Critical for Drug Development.
8: Chirality in Agrochemicals.
9: The Use of New Phosphines as Powerful Tools in Asymmetric Synthesis of Biologically Active Compounds.
10: Chirality and Combinatorial Libraries for Drug Discovery, An Overview.
Half Title Page.
Title Page.
Copyright Page.
Contributors.
Contents.
Preface.
1: Introductory Remarks: Chiral Pool Syntheses and Diastereoselective Reactions.
2: General Principles of Diastereoselective Reactions: Rigid Templates.
3: General Principles of Diastereoselective Reactions: Diastereoselectivity via Substrate-Directable Reactions (Internal Delivery) and Heterocyclizations.
4: General Principles of Diastereoselective Reactions: Acyclic Control of Diastereoselectivity.
5: General Principles of Diastereoselective Reactions: Diastereoselective Domino Reactions.
6: Chiral Pool Synthesis: From α-Amino Acids and Derivatives.
7: Chiral Pool Synthesis: Starting from Terpenes.
8: Chiral Pool Synthesis: Chiral Pool Syntheses Starting from Carbohydrates.
9: Chiral Pool Synthesis: Chiral Pool Syntheses from cis-Cyclohexadiene Diols.
10: Chiral Pool Synthesis: Chiral Pool Synthesis from Hydroxy Acids: Lactic Acid, Tartaric Acid, Malic Acid, and 2-Methyl-3-Hydroxypropionic Acid.
11: Chiral Pool Synthesis: Chiral Pool Synthesis from Quinic Acid.
12: Selected Diastereoselective Reactions: Additions of Achiral Carbanions