Estrogen Action, Selective Estrogen Receptor Modulators And Women's Health: Progress And Promise

Publisher Imperial College Press

Format

eBook

2nd Edition 1st Edition

Quantity

Add New

Publisher

Imperial College Press

Volume

Copyright

2013

ISBN13

9781848169586

Release

Format

eBook

Grade Level

College Freshman - College Senior

DDC
TBD

Overview

This volume presents the evolution of the authors ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of womens health and reproduction. The book is a journey through 40 years of discovery and success in advancing womens health, with the prospect of improved innovation through medicinal chemistry for the future.
Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Dedication.
Contents.
About the Author and Editor.
Contributors.
Acknowledgements.
Forewords.
Other Front Matter.
Introduction: The Foundation of a Career.
1: A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention.
2: Diethylstilbestrol: A Tragedy in Reproductive Endocrinology but a Pioneering Cancer Treatment.
3: Oral Contraceptives and Women's Health.
4: Hormone Replacement Therapy and Women's Health.
5: Induction of Ovulation by Nonsteroidal Antiestrogens.
6: Clues about Estrogen and Antiestrogen Action from X-Ray Crystallography.
7: Coregulators and Their Role in Selective Estrogen Receptor Modulator Action.
8: Role of Estrogen in Familial Breast Cancer.
9: Advances with Aromatase Inhibitors.
10: Adjuvant Antihormone Therapy.
11: Pharmacogenomics of Tamoxifen.
12: Antihormone Drug Resistance.
13: Novel Selective Estrogen Receptor Modulators.
14: Endocrine Prevention of Breast Cancer.
15: Selective Androgen Receptor Modulators as Improved Androgen Therapy for Women.
16: An Emerging Principle: Selective Nuclear Receptor Modulators.
Appendices.
Appendix 1: Scientific Survival Suggestions.
Appendix 2: Decades of Discovery: The SERM Story — The St. Gallen Prize.
Appendix 3: An Account of Students Obtaining a Ph.D. Degree (or an M.D. for Physicians in the British System) while in the Tamoxifen Team Over the Last 30 Years.
Index.
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Estrogen Action, Selective Estrogen Receptor Modulators And Women's Health: Progress And Promise

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