This book builds upon its previous edition by comprehensively updating important epidemiologic and clinical content of the HIV continuum amongst Black and Latino individuals of the United States, including the epidemiology, prevention, diagnosis, and treatment of HIV within these diverse communities. Illuminating current diagnostic and prevention considerations, as well as its evidence base, the text highlights important concepts and integrates critical aspects of the structural and social environment, such as mass incarceration and neighborhood-level disadvantage, that compromise our ability to decrease HIV risk and improve outcomes. Discussion regarding significant predictors of health inequity, including discrimination, medical mistrust, and stigma, specifically homophobia and transphobia, are included. The book also reviews the impact of significant advances in HIV prevention, such as pre-exposure prophylaxis (PrEP), within Black and Latino communities. Written by experts in their field, this edition is a comprehensive and dynamic resource for all health care providers who support the care and treatment of Black and Latino individuals at risk for or living with HIV.