In 1997, Melissa Levin, Priya Chowdhury, Tara Taylor, and Suki Hammer are going places. Their yearbook superlatives confirm it: Most Likely to Win the White House, Cure Cancer, Open a Michelin-Starred Restaurant, and Join the Forbes 400. Fast forward twenty-five years and nothing has gone according to plan. Fueled by nostalgia, they form a pact to push through their middle-aged angst to bring their teenage aspirations to fruition, dubbing themselves the "Most Likely Girls." Through the ensuing highs and lows, they are reminded of the bonds of friendship, the ways our childhood dreams both sustain and surprise us, and why it's deeply uncool to peak in high school.